Lechleitner M, Kaser S, Hoppichler F, Roden M, Weitgasser R, Ludvik B, Fasching P, Winhofer-Stöckl Y, Kautzky-Willer A, Schernthaner G, Prager R, Wascher TC, Clodi M. Wien Klin Wochenschr. Insulin glargine 300 U/mL was generally associated with a lower risk of nocturnal hypoglycaemia than insulin glargine 100 U/mL in insulin-experienced patients with type 2 diabetes, while the risk of nocturnal hypoglycaemia did not significantly differ between treatment groups in insulin-naïve patients with type 2 diabetes or in patients with type 1 diabetes. Talk with your doctor before you drink alcohol or take products that have alcohol in them. Some drugs may have another patient information leaflet. If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot. Check with your pharmacist. Case Report: High-concentration Insulin Glargine Overdose Complicated by Hepatic Steatosis. Check your blood sugar as you have been told by your doctor. This is not a list of all drugs or health problems that interact with this medicine (insulin glargine pens). Toujeo (insulin glargine injection) 300 Units/mL is a long-acting insulin injection which helps control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus. Reacții adverse. to make sure that it is safe for you to take this medicine (insulin glargine pens) with all of your drugs and health problems. Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus. 2019 May;131(Suppl 1):39-46. doi: 10.1007/s00508-019-1492-7. Für Insulin glargin 300 Einheiten/ml wurde in Studien im Vergleich zu Insulin glargin 100 Ein- 2017 Oct;43(5):446-452. doi: 10.1016/j.diabet.2017.03.001. Do not share your insulin product with another person. Nach acht Wochen wurden die … Do not freeze. Do not drive if your blood sugar has been low. eCollection 2020 May 1. Previous research showed the two drugs had similar HbA1c reduction but less hypoglycemia episodes. If it is close to the time for your next shot, skip the missed shot and go back to your normal time. Other Name: HOE901, Toujeo, Gla-300. There is a greater chance of you having a crash. Talk with a doctor or pharmacist if you have any questions. Insulina glargin se poate prezenta sub forma insulina glargin 100 unitati/ml (echivalent cu 3,64 mg) inovativ sau biosimilar si insulina glargin 300 unitati/ml (echivalent cu 10,91 mg). Take off the needle after each shot. Do NOT reuse needles. These improvements in glycaemic control were maintained during longer-term (12 months) treatment. Das Mahlzeiteninsulin wurde unverändert beibehalten. Clipboard, Search History, and several other advanced features are temporarily unavailable. Insulina glargin este un analog de insulină umană cu durată lungă de acţiune produs prin tehnologia ADN-ului recombinant pe tulpini de Escherichia coli. Talk with the doctor. Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine (insulin glargine pens) affects you. Please enable it to take advantage of the complete set of features! Toate insulinele și analogii de insulină injectabilă pot produce hipoglicemie și reacții la locul injectării (durere, edeme, lipodistrofie). COVID-19 is an emerging, rapidly evolving situation. Be sure that you You could have more side effects. It is approved only for use in patients aged ≥ 18 years. Tell your Insulin pens and needles must never be shared between patients. To conclude, once-daily subcutaneous insulin glargine 300 U/mL is an effective and generally well tolerated basal insulin therapy option for patients with type 1 or type 2 diabetes. [Diagnosis and insulin therapy of type 1 diabetes mellitus (Update 2019)]. You may report side effects to the FDA at 1-800-332-1088. Doing so may lead to very bad side effects or life-threatening low blood sugar. We comply with the HONcode standard for trustworthy health information -, Detailed Insulin glargine dosage information. If you have any questions about this medicine (insulin glargine pens), please talk Call your doctor for medical Insulina glargin se poate prezenta sub forma insulina glargin 100 unitati/ml (echivalent cu 3,64 mg ) inovativ sau biosimilar si insulina glargin 300 unitati/ml (echivalent cu 10,91 mg). The aim of the trial is to compare the efficacy and safety of insulin degludec and insulin glargine 300 units/mL in subjects with type 2 diabetes mellitus inadequately treated with basal insulin with or without oral antidiabetic drugs. metformin, Trulicity, Lantus, Victoza, Tresiba, Levemir, Novolog, Basaglar, Toujeo. -, Diabetes Care. It is given as a shot into the fatty part of the skin on the top of the thigh, belly area, or upper arm. Insulin glargine 300 U/mL (Toujeo(®)) is a long-acting basal insulin analogue approved for the treatment of diabetes mellitus. Tell all of your health care providers that you take this medicine (insulin glargine pens). Glucose clamp studies confirm that Gla-300 provides flatter and more prolonged pharmacokinetic and pharmacodynamic profiles than Gla-100 (12, 13). Insulin glargin (Insulinum glarginum; Handelsnamen: Toujeo, Lantus) ist ein Arzneistoff aus der Gruppe der Insulinanaloga, der zur Behandlung der Zuckerkrankheit (Diabetes mellitus) eingesetzt wird, und zählt zu den Basal-Insulinen.Der Wirkstoff ist ein rekombinantes Protein, das aus gentechnisch veränderten Mikroorganismen hergestellt wird. Throw away needles in a needle/sharp disposal box. Terauchi Y, Koyama M, Cheng X, Sumi M, Riddle MC, Bolli GB, Hirose T; EDITION JP 2 study group. Bethesda, MD 20894, Copyright If you are 65 or older, use this medicine (insulin glargine pens) with care. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Do not use if the solution is cloudy, leaking, or has particles. it, talk with the doctor. 2020 Apr 28;10(4):e033659. Last updated on Nov 17, 2020. The concentration of insulin glargine in Toujeo is 300 units per mL. Do not Be sure you have the right insulin product. Drug: INSULIN GLARGINE (U300) Pharmaceutical form: Solution for injection in a prefilled pen. If you have questions, talk with the doctor. pharmacist if you have questions about the best way to throw out drugs. 2018 Feb;20(2):448-452. doi: 10.1111/dom.13071. HealthDay News — For older adults, insulin glargine 300 units/mL (Gla-300) is safe and as effective as Gla-100, with a similarly low or lower risk of symptomatic hypoglycemia, according to a study published online June 12 in Diabetes Care . getting rid of it. you need to throw it away. Store opened pens at room temperature. En napolnjen injekcijski peresnik vsebuje 300 enot insulina glargin in 100 mikrogramov liksisenatida v 3 ml raztopine. Diabetes Obes Metab. Diabetes Metab. -, Diabetes Care. -, Diabetes Obes Metab. Insulin pens and needles must never be shared between patients. Epub 2018 Nov 26. 2020 Apr 22;4(5):bvz020. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. In die Studien wurden über 3.500 Erwac… Wear disease medical alert ID (identification). Check with your Signs may be dizziness. Learn more. However, many people have no side effects or only have minor side effects. 2015 Jan;38(1):140-9 This site needs JavaScript to work properly. Very low blood sugar can lead to. Diabetes Obes Metab. It may be harder to control blood sugar during times of. doi: 10.1210/jendso/bvz020. Insulin glargine, marketed under the names Lantus among others, is a long-acting insulin, used in the management of type I and type II diabetes. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. Diabetes Obes Metab. Signs of an allergic reaction, like rash; Signs of infection like fever, chills, very bad. If you are not sure, talk with the doctor or pharmacist. Modify insulin regimens only under medical supervision. Die Entscheidung der Europäischen Kommission für die Zulassung von Insulin glargin U300 beruht auf den Ergebnissen des klinischen Studienprogramms EDITION, einer weltweiten umfangreichen Reihe an Phase-III-Studien, die die Wirksamkeit und Sicherheit von Insulin glargin U300 im Vergleich zu Insulin glargin U100 (Insulin glargin zur Injektion U100, 100 Einheiten/ml; Lantus®) untersuchten. has been changed. Those trials did not look at direct clinical comparisons. Insulin glargine 300 IU/mL solution (Gla-300) is a basal insulin, administered subcutaneously once daily. • Insulin glargin 300 Einheiten/ml ist in zwei unterschiedlichen Fertigpens erhältlich: Wenn Sie Insulin glargin 300 E/ml (Toujeo ®) verschrieben bekommen, müssen Sie von Ihrem Arzt oder dem medizinischen Fachpersonal in der Anwendung Ihres Toujeo ®-Pens geschult werden. Insulin glargine (U300) (Gla-300) once daily for 26 weeks on top of any other antidiabetic treatment except other basal insulin. This medicine must not be used in an insulin pump. Outcome Measures . En mililiter vsebuje 100 enot insulina glargin in 33 mikrogramov liksisenatida. 2015 Apr;17(4):386-94. doi: 10.1111/dom.12438. the right dose of this medicine (insulin glargine pens). Doing so could lead to Take a missed dose as soon as you think about it. -. It comes in a prefilled pen that you must use to take your dose. Medically reviewed by Drugs.com. Do NOT reuse needles. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Do not refrigerate. any drug without checking with your doctor. If you have any questions, call your doctor or pharmacist. Do not share your drugs with others and do not take anyone else's drugs. Data sources include IBM Watson Micromedex (updated 1 Apr 2021), Cerner Multum™ (updated 5 Apr 2021), ASHP (updated 6 Apr 2021) and others. Throw away unused or expired drugs. Modify insulin regimens only under medical supervision. problems, and sometimes death. 2019 Sep;45(4):330-340. doi: 10.1016/j.diabet.2018.11.004. Insulin glargine 300 U/mL has a more stable and prolonged pharmacokinetic/pharmacodynamic profile than insulin glargine 100 U/mL (Lantus(®)), with a duration of glucose-lowering activity exceeding 24 h. In several 6-month phase III trials, insulin glargine 300 U/mL achieved comparable glycaemic control to that seen with insulin glargine 100 U/mL in patients with type 1 or type 2 diabetes, albeit with consistently higher daily basal insulin requirements. advice about side effects. Basal insulin analogs like degludec 100 units/mL and glargine 300 units/mL have been created for an ultralong effect but have not been studied in comparison with each other for efficacy. J Endocr Soc. Sharing may pass infections from one person to another. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. taken, how much, and when it happened. Prevention and treatment information (HHS). Insulin glargin gehört zur Klasse der langwirksamen Insulin-Analoga und wird als Basal-Insulin zur Therapie des Diabetes mellitus eingesetzt. „Das höher konzentrierte Insulin glargin 300 E/ml bildet im Vergleich zu Insulin glargin 100 E/ml nach der subkutanen Injektion ein kompakteres Depot mit einer reduzierten Oberfläche“, so Professor Dr. Thomas Forst, Mannheim.³ ⁴ Daraus resultiert eine langsamere und länger anhaltende Insulinfreisetzung sowie ein stabiles Wirkprofil über mehr als 24 Stunden.³ ⁵ ⁶ Insulin glargin 300 E/ml zeigt darüber hinaus nur geringe Schw… Monitor blood glucose in all patients treated with insulin. What is Toujeo ® (insulin glargine injection) 300 Units/mL? When the box is full, follow all local rules for Move site where you give the shot each time. Insulin glargine 300 U/mL (Toujeo (®)) is a long-acting basal insulin analogue approved for the treatment of diabetes mellitus. Do not flush down a toilet or pour down a drain unless you are told to do so. 2015 Sep;17(9):835-42 Glargine 300 is associated with significantly lower annualized rates of documented symptomatic hypoglycemia than Gla-100. Do not give into skin that is thickened, or has pits or lumps. Effects generally begin an hour after use. Would you like email updates of new search results? Utilizări medicale. Accessibility În timpul primelor săptămâni, această reducere trebuie compensată, cel puţin parţial, prin creşterea Do not move this medicine (insulin glargine pens) from the pen to a syringe. If an unopened container has been stored at room temperature, be sure you know how long you can leave this medicine (insulin glargine pens) at room temperature before Insulin glargin: Wirkstoff-Monographien. In the T2DM EDITION trials, patients receiving Gla-300 required 11-15% more basal insulin than those receiving Gla-100. Epub 2015 Feb 12. The dose of rapid acting insulin was similar between the 2 groups. Sanofi hat bekanntgegeben, dass der Ausschuss für Human-arzneimittel (CHMP) der Europäischen Arzneimittelagentur (EMA) eine positive Empfehlung zur Erteilung der Zulassung für Insulin glargin U300 (Insulin glargin zur Injektion, 300 Einheiten/ml), einem Basalinsulin der nächsten Generation zur Behandlung von Erwachsenen mit Diabetes Typ 1 oder Typ 2, abgegeben hat. It is typically the recommended long acting insulin in the United Kingdom. 2019 May;131(Suppl 1):77-84. doi: 10.1007/s00508-019-1493-6. Talk with the doctor. It is used to lower blood sugar in patients with high blood sugar (diabetes). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not mix this insulin in the same syringe with other types of insulin. Linkedin. Glar-300 has one-third the injection volume of Glar-100 and offers a more even and prolonged PK/PD profile that lasts beyond 24 h. To increase the concentration from 100 to 300 U/mL (following subcutaneous administration) under usual conditions at physiological pH, insulin Glar normally precipita… Do not store this device with the needle on it. Teilen. Această insulină prezintă o acțiune de lungă durată. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Results: The serum insulin glargine concentration (INS) and glucose infusion rate (GIR) developed more gradually into more constant and prolonged profiles with Gla-300 than with Gla-100. Medically reviewed by Drugs.com. Twittern. You must check Rationale and methodology for a European pooled analysis of postmarketing interventional and observational studies of insulin glargine 300 U/mL in diabetes: protocol of REALI project. Efficacy and Safety of Insulin Glargine 300 U/mL versus 100 U/mL in Diabetes Mellitus: A Comprehensive Review of the Literature. Insulin glargin 100 Einheiten/ml und Insulin glargin 300 Einheiten/ml (Toujeo ®) sind nicht bioäquivalent und nicht direkt austauschbar. Generic Name: Insulin Glargine (U-300) Pens (IN soo lin GLAR jeen) Brand Name: Lantus Solostar, Toujeo Max SoloStar, Toujeo SoloStar. [Insulin therapy of type 2 diabetes mellitus (Update 2019)]. Generic Name: Insulin Glargine (U-300) Pens (IN soo lin GLAR jeen)Brand Name: Lantus Solostar, Toujeo Max SoloStar, Toujeo SoloStar. It is used once a day as an injection just under the skin. Patients will require a higher dose of Gla-300 to achieve glycemic control similar to Gla-100. Wie bei jedem Insulinwechsel muss eine patientenindividuelle Einstel-lung erfolgen. This brand of insulin has 3 times as much insulin as other brands. • Insulina glargin 300 unităţi/ml (Toujeo) şi insulina glargin 100 unităţi/ml (Lantus) nu sunt bioechivalente şi, prin urmare, nu sunt interschimbabile fără ajustarea dozei (aceasta înseamnă că aceste insuline nu sunt la fel şi nu trebuie să treceţi de la o insulină la alta fără să vi se ajusteze doza). Be ready to tell or show what was eCollection 2018. … Low blood potassium may happen with this medicine (insulin glargine pens). Do not prepare the dose by counting the clicks. Take this medicine (insulin glargine pens) at the same time of day. using the wrong dose. Glar-300 was developed to address the duration concerns of the early basal analogues. Gegenanzeigen von TOUJEO 300 E/ml SoloStar Inj.-Lsg.i.e.Fertigpen Beschreibt, welche Erkrankungen oder Umstände gegen eine Anwendung des Arzneimittels sprechen, in welchen Altersgruppen das Arzneimittel nicht eingesetzt werden sollte/darf und ob Schwangerschaft und Stillzeit gegen die Anwendung des Arzneimittels sprechen. know how to measure and get your dose ready. If not treated, this can lead to a heartbeat that is not normal, very bad breathing Shortness of breath, a big weight gain, or swelling in the arms or legs. Privacy, Help If you have any of these health problems: Acidic blood problem or. New insulin glargine 300 U/ml compared with glargine 100 U/ml in insulin-naïve people with type 2 diabetes on oral glucose-lowering drugs: a randomized controlled trial (EDITION 3). Insulin glargin – statt Toujeo® ... Abasaglar® (U100) verordnen Die Firma Sanofi-Aventis hat nach dem Patentablauf von Lantus® (U100) eine U-300-Formulierung (Toujeo®)1 des Insulin glargins in den Markt eingeführt. New phase III study results are showing positive outcomes with U300 performing the same in controlling blood glucose as insulin glargine but with less hypoglycemia during the day and night. If your symptoms or health problems do not get better or if they become worse, call your doctor. 2018 Feb 12;2018:2052101. doi: 10.1155/2018/2052101. Route of administration: Subcutaneous. Available for Android and iOS devices. You may also report side effects at https://www.fda.gov/medwatch. Do not reuse needles or other items. Monitor blood glucose in all patients treated with insulin. Insulin glargine 300 U/mL has a more stable and prolonged pharmacokinetic/pharmacodynamic profile than insulin glargine 100 U/mL (Lantus (®)), with a duration of glucose-lowering activity exceeding 24 h. Be sure to use How long can Toujeo stay out of the refrigerator? with your doctor, nurse, pharmacist, or other health care provider. The concentration of insulin glargine in Toujeo is 300 units per mL. If you are not sure what to do if you miss a dose, call your doctor. Store unopened pens in a refrigerator. tratament insulina bazală, de la insulină glargin 300 unităţi/ml administrată o dată pe zi, la Lantus administrat o dată pe zi, trebuie să reducă doza cu aproximativ 20%. 2015 Apr;17(4):386-94 Lechleitner M, Clodi M, Abrahamian H, Brath H, Brix J, Drexel H, Fasching P, Föger B, Francesconi C, Fröhlich-Reiterer E, Harreiter J, Hofer SE, Hoppichler F, Huber J, Kaser S, Kautzky-Willer A, Ludvik B, Luger A, Mader JK, Paulweber B, Pieber T, Prager R, Rami-Merhar B, Resl M, Riedl M, Roden M, Saely CH, Schelkshorn C, Schernthaner G, Sourij H, Stechemesser L, Stingl H, Toplak H, Wascher TC, Weitgasser R, Winhofer-Stöckl Y, Zlamal-Fortunat S. Wien Klin Wochenschr. Use this medicine (insulin glargine pens) as ordered by your doctor. Diabetes Obes Metab. to you and the baby. doi: 10.1136/bmjopen-2019-033659. This product may make a clicking sound as you prepare the dose. Empfehlen. 2015 Dec;17(12):1107-14. doi: 10.1111/dom.12531. In the T1DM trial, the Gla-300 group required 17.5% more basal insulin than the Gla-100 group. If you think there has been an overdose, call your poison control center or get medical care right away. Call your doctor or get medical Like Glar-100, Glar-300 contains insulin Glar, a 21A-Gly modified mimic of the final intermediate of natural human insulin. Facebook. Do not start, stop, or change the dose of Keep all drugs in a safe place. Remove all pen needle covers before injecting a dose (there may be 2). Low blood sugar may occur. The new insulin glargine 300 units/mL (Gla-300) has a reduced redissolution rate following subcutaneous injection as compared with Gla-100 and thereby the potential for meeting this need (12, 13). Roussel R, d'Emden MC, Fisher M, Ampudia-Blasco FJ, Stella P, Bizet F, Cali AMG, Wysham CH. If you have questions about side effects, call your doctor. J Diabetes Res. Freemantle N, Bonadonna RC, Gourdy P, Mauricio D, Mueller-Wieland D, Bigot G, Ciocca A, Mauquoi C, Rollot M, Bonnemaire M. BMJ Open. Gla-300 than Gla-100 (0.86% vs. 0.69. Last updated on Nov 17, 2020. Epub 2017 Sep 14. Careers. This includes any pens, cartridge devices, needles, or syringes, even if the needle use a syringe to remove insulin from the pen. Do not give into skin that is irritated, tender, bruised, red, scaly, hard, scarred, or has stretch marks. I. Criterii de includere pentru tratamentul cu insulină glargine Low blood sugar may happen with this medicine (insulin glargine pens). . National Library of Medicine •Insulina glargin 300 unităţi/ml (Toujeo) şi insulina glargin 100 unităţi/ml (Lantus) nu sunt bioechivalente şi, prin urmare, nu sunt interschimbabile fără ajustarea dozei (aceasta înseamnă că aceste insuline nu sunt la fel şi nu trebuie să treceţi de la o insulină la alta fără să vi se ajusteze doza). You will need to talk about the benefits and risks FOIA Insulin glargin U300 bringt eine weitere Verbesserung wie eine vierarmige Parallelgruppenstudie, die auf kontinuierlichen Glukosemessungen (CGM) basierte, zeigt: Die Teilnehmer applizierten randomisiert einmal täglich – morgens oder abends – Insulin glargin U300 oder Insulin glargin U100. Uses; Before taking; Warnings; Dosage; Side effects; Storage; FAQ; Uses of Insulin Glargine Pens: It is used to lower blood sugar in patients with high blood sugar (diabetes). 8600 Rockville Pike Throw away any part not used after 56 days. Follow the diet and workout plan that your doctor told you about. 2015 Aug;39(4):335-43 If you are not sure what type of pen needle you have or how to use Thick skin, pits, or lumps where the injection was given. U300 is a new formulation of insulin glargine that is expected to last up to 40h. Owens DR, S Bailey T, Fanelli CG, Yale JF, Bolli GB. Epub 2017 Apr 19. help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. Unable to load your collection due to an error, Unable to load your delegates due to an error. Durchgreifende medizinische Vorteile für eine Umstellung oder für eine bevorzugte Verwendung von Toujeo® sehen wir zum jetzigen Zeitpunkt nicht. Epub 2015 Sep 10. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Insulin glargine, recombinant Subcutaneous. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. • Insulin glargine 300U/ml (Glar-300) is a long-acting basal insulin analogue with a low injection volume and less pharmacokinetic and pharmacodynamic variability than standard glargine 100U/ml (Glar-100) • In patients with type 2 diabetes (T2D), the efficacy of Glar-300 in terms of glycaemic control is Follow all instructions closely. Talk with the doctor. Insulina glargin este utilizată în tratamentul diabetului zaharat de tip 1 sau a de tip 2 (non-insulino-dependent), în tratament de lungă durată. This includes infections you may not know you have. A review of the safety and efficacy data for insulin glargine 300 units/ml, a new formulation of insulin glargine. Glycaemic control and hypoglycaemia in people with type 2 diabetes switching from twice-daily basal insulin to once-daily insulin glargine 300 U/mL or insulin glargine 100 U/mL (EDITION 1 and EDITION 2 subgroup analysis). Diabetes Metab. Xing. Have blood work checked as you have been told by the doctor. mL −1 (Gla-100) at steady state in people with type 1 diabetes. Bolli GB, Riddle MC, Bergenstal RM, Ziemen M, Sestakauskas K, Goyeau H, Home PD; on behalf of the EDITION 3 study investigators. 2015 Apr;38(4):637-43 There may be drug take-back programs in your area. What is the difference between Soliqua and Xultophy? Do not take 2 doses at the same time or extra doses. Clinical relevance of pharmacokinetic and pharmacodynamic profiles of insulin degludec (100, 200 U/mL) and insulin glargine (100, 300 U/mL) - a review of evidence and clinical interpretation. Read all information given to you. Keep all drugs out of the reach of children and pets. This includes your doctors, nurses, pharmacists, and dentists. Insulin products come in many containers like vials, cartridges, and pens. Similar efficacy and safety to that of insulin glargine 100 IU/mL solution (Gla-100) Gla-300 is a concentrated formulation of the already PBS-listed Gla-100. In support of this, the times to 50% of glargine exposure and insulin activity were longer for all Gla-300 doses than for Gla-100 during the 36-h clamp period, indicating a more evenly distributed exposure and metabolic effect beyond 24 h. Exposure to insulin glargine … Glycaemic control and hypoglycaemia with insulin glargine 300 U/mL compared with glargine 100 U/mL in Japanese adults with type 2 diabetes using basal insulin plus oral anti-hyperglycaemic drugs (EDITION JP 2 randomised 12-month trial including 6-month extension). -, Can J Diabetes. Toujeo vs Tresiba - What's the difference between them?
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