40 Aluminum Lake, FD&C Blue No. 3400930121443 (2017, RCP rév 29.01.2021) 90 cp 125 µg (plaq PVC/Alu). Round shaped, Turquoise colored, uncoated tablets, break line on both side and debossed with "P" and "8" on one side and plain on other side. Carefully monitor glycemic control after starting, changing, or discontinuing Levothyroxine sodium [see Drug Interactions (7.2)] . Short-term administration of large doses of glucocorticoids may decrease serum T3 concentrations by 30% with minimal change in serum T4 levels. Atrial fibrillation is the most common of the arrhythmias observed with Levothyroxine overtreatment in the elderly. In patients treated with large doses of propranolol (> 160 mg/day), T3 and T4 levels change, TSH levels remain normal, and patients are clinically euthyroid. Instruct patients to notify their healthcare provider if they experience any of the following symptoms: rapid or irregular heartbeat, chest pain, shortness of breath, leg cramps, headache, nervousness, irritability, sleeplessness, tremors, change in appetite, weight gain or loss, vomiting, diarrhea, excessive sweating, heat intolerance, fever, changes in menstrual periods, hives or skin rash, or any other unusual medical event. Monitor for cardiac arrhythmias during surgical procedures in patients with coronary artery disease receiving suppressive Levothyroxine sodium therapy. BOITE DE 30. Adverse reactions associated with Levothyroxine sodium therapy are primarily those of hyperthyroidism due to therapeutic overdosage [see Warnings and Precautions (5), Overdosage (10)] . Euthyrox 50µg Comprimés x 100 : La lévothyroxine, substance active d’Euthyrox, est une hormone thyroïdienne synthétique destinée au traitement Levothyroxine is given when your thyroid does not produce enough of this hormone on its own. The increased bone resorption may be associated with increased serum levels and urinary excretion of calcium and phosphorous, elevations in bone alkaline phosphatase, and suppressed serum parathyroid hormone levels. These drugs may increase serum thyroxine-binding globulin (TBG) concentration. Obtain serum T4 and TSH levels at the end of the trial period, and use laboratory test results and clinical assessment to guide diagnosis and treatment, if warranted. EUTHYROX contains the active ingredient, levothyroxine, a synthetic crystalline levothyroxine (T4) in sodium salt form.It is chemically designated as L-3,3',5,5'-tetraiodothyronine monosodium hydrate. Patients with panhypopituitarism or other causes predisposing to adrenal insufficiency may react to levothyroxine treatment, and it is advisable to start corticosteroid therapy before giving levothyroxine … Levothyroxine is also used to treat or prevent goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer. There is a long experience of Levothyroxine use in pregnant women, including data from post-marketing studies that have not reported increased rates of fetal malformations, miscarriages or other adverse maternal or fetal outcomes associated with Levothyroxine use in pregnant women. Round shaped, Olive colored, uncoated tablets, break line on both side and debossed with "P" and "4" on one side and plain on other side. Untreated maternal hypothyroidism may have an adverse effect on fetal neurocognitive development. Seizures occurred in a 3-year-old child ingesting 3.6 mg of Levothyroxine. Levothyroxine is a prescription drug. Thyroid hormones, including Levothyroxine sodium, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. Des doses substantielles peuvent provoquer des effets indésirables graves, voire potentiellement mortels. get them into normal TSH (thyroid stimulating hormone) range, and thyroid treatment. Potential impact: Concurrent use may reduce the efficacy of Levothyroxine sodium by binding and delaying or preventing absorption, potentially resulting in hypothyroidism. The majority of the Levothyroxine sodium dose is absorbed from the jejunum and upper ileum. Start with a lower dose in elderly patients, patients with underlying cardiovascular disease or patients with severe longstanding hypothyroidism as described above. Evaluate serum TSH every 4 weeks and adjust Levothyroxine sodium tablets dosage until a serum TSH is within the normal trimester specific range [see Use in Specific Populations (8.1)] . 2 Aluminum Lake, FD&C Blue No. Therefore, a decrease in the dose of anticoagulant may be warranted with correction of the hypothyroid state or when the Levothyroxine sodium dose is increased. A conserver à une température ne dépassant pas 25 °C dans l'emballage d'origine. Absorption may also decrease with age. Round shaped, White colored, uncoated tablets, break line on both side and debossed with "P" and "2" on one side and plain on other side. Failure of the serum T4 to increase into the upper half of the normal range within 2 weeks of initiation of Levothyroxine sodium therapy and/or of the serum TSH to decrease below 20 IU per litre within 4 weeks may indicate the child is not receiving adequate therapy. 3400930157954 (2018, RCP rév 29.01.2021) 90 cp 88 µg (plaq PVC/Alu). Pregnancy may increase Levothyroxine sodium requirements. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Le contrôle de la TSH doit être réalisé entre 6 et 8 semaines après le changement, sauf chez les femmes enceintes où les modalités de surveillance sont à adapter en fonction de l'évolution de la pathologie thyroïdienne et du terme de la grossesse. Common side effects of Levothyroxine : Feeling more or less hungry. 6 Aluminum Lake, FD&C Yellow No. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. 1 Aluminum Lake, manufacture(16729-447), analysis(16729-448, 16729-449, 16729-450, 16729-451, 16729-452, 16729-453, 16729-454, 16729-455, 16729-456, 16729-457, 16729-458), Levothyroxine sodium tablets are not indicated for suppression of benign thyroid nodules and nontoxic diffuse goiter in iodine-sufficient patients as there are no clinical benefits and overtreatment with Levothyroxine sodium may induce hyperthyroidism. This medicine is given when your thyroid does not produce enough of this hormone on its own. Hypersensitivity to Levothyroxine itself is not known to occur. Changes in thyroid status may occur if barbiturates are added or withdrawn from patients being treated for hypothyroidism. En désactivant ces cookies, vous ne pourrez plus partager les articles depuis le site VIDAL sur les réseaux sociaux. Reduce Levothyroxine sodium dosage to pre-pregnancy levels immediately after delivery and measure serum TSH levels 4 to 8 weeks postpartum to ensure Levothyroxine sodium dose is appropriate. Closely monitor TSH levels in such patients. LEVOTHYROX 50 µg Cpr séc Plq préd PVC/Alu/30, Vidal France vous informe qu'en naviguant sur ce site internet des cookies ayant une finalité de mesure de l’audience sont utilisés par Vidal France aux fins de produire des statistiques anonymes. Agréé aux Collectivités. Each Levothyroxine sodium tablet contains the inactive ingredients microcrystalline sodium, light magnesium oxide, sodium starch glycolate and sodium stearyl fumarate. Levothyroxine is used to treat an underactive thyroid gland (hypothyroidism).It replaces or provides more thyroid hormone, which is normally produced by the thyroid gland. Levothyroxine should be introduced very gradually in patients aged over 50 years (see section 4.2) and those with long standing hypothyroidism to avoid any sudden increase in metabolic demands. Reduce the Levothyroxine sodium dose or discontinue temporarily if signs or symptoms of overdosage occur. Closely monitor blood pressure and heart rate in these patients. New Onset Hypothyroidism: Normalize thyroid function as rapidly as possible. Levothyroxine is used to treat hypothyroidism (low thyroid hormone) Cụ thể, nhiều trang website đưa thông tin về sản phẩm Levothyrox 50 μg mà lại viết là Levothyrox 50mg hay Levothyrox 100μg lại viết là Levothyrox 100mg. L'intelligence médicale au service du soin, LEVOTHYROXINE SODIQUE 50 µg cp (LEVOTHYROX), Médicaments de l'axe hypophyso-thyroïdien, HORMONES SYSTEMIQUES, HORMONES SEXUELLES EXCLUES, VIDAL est signataire de la charte de la E-SANTÉ, Bien utiliser ses produits de parapharmacie, Recherche par nom de produit de parapharmacie, Fiches patients - Comprendre l'hypothyroïdie, Fiches patients - Traitement par hormones thyroïdiennes. 3400930065686 (2010, RCP rév 29.01.2021) 90 cp 50 µg (plaq PVC/Alu). Dosage. 3400930158166 (2018, RCP rév 29.01.2021) 30 cp 137 µg (plaq PVC/Alu). Par conséquent, le traitement par substitution en lévothyroxine est possible pendant l'allaitement. The final daily dose may be up to 50 to 200 micrograms. 3400930158074 (2018, RCP rév 29.01.2021) 90 cp 112 µg (plaq PVC/Alu). Pharmaceutical form: 50 & 100mcg tablets. Furosemide has been shown to inhibit the protein binding of T4 to TBG and albumin, causing an increase free T4 fraction in serum. Levothyroxine is generally continued for life in these patients. Levothyroxine Sodium Tablets Color Additives, Table 7. L'hypothyroïdie ou l'hyperthyroïdie sont susceptibles d'affecter la fertilité. La surveillance clinique et biologique doit être renforcée le plus précocement possible, dès la découverte de la grossesse et, poursuivie tout particulièrement pendant la 1re moitié de la grossesse, afin d'adapter rapidement et régulièrement le traitement si nécessaire. Chez les femmes allaitantes équilibrées en hormone T4, la lévothyroxine est excrétée dans le lait maternel à de faibles concentrations. Uttarakhand 248197, Levothyroxine sodium tablets are indicated as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism. 25 µg (équivalant à 24,31 µg de lévothyroxine), 50 µg (équivalant à 48,62 µg de lévothyroxine), 75 µg (équivalant à 72,96 µg de lévothyroxine), 88 µg (équivalant à 85,58 µg de lévothyroxine), 100 µg (équivalant à 97,28 µg de lévothyroxine), 112 µg (équivalant à 108,92 µg de lévothyroxine), 125 µg (équivalant à 121,59 µg de lévothyroxine), 137 µg (équivalant à 133,23 µg de lévothyroxine), 150 µg (équivalant à 145,90 µg de lévothyroxine), 175 µg (équivalant à 170,18 µg de lévothyroxine), 200 µg (équivalant à 194,60 µg de lévothyroxine). Start Levothyroxine sodium tablets at the full replacement dose in otherwise healthy, non-elderly individuals. Titrate the dose of Levothyroxine sodium carefully and monitor response to titration to avoid these effects [see Dosage and Administration (2.4)] . What Euthyrox contains. La gravité des manifestations cliniques n'est ni corrélée à la dose ingérée ni au dosage sérique de T4 et T3. For most patients older than 50 years or for patients under 50 years of age with underlying cardiac disease, an initial starting dose of 25-50 mcg/day of levothyroxine sodium is recommended, with gradual increments in dose at 6-8 week intervals, as needed. Instruct patients to notify their physician of any other medical conditions they may have, particularly heart disease, diabetes, clotting disorders, and adrenal or pituitary gland problems, as the dose of medications used to control these other conditions may need to be adjusted while they are taking Levothyroxine sodium tablets. Effect of not taking medicine after thyroid removal? Undertreatment may result in poor school performance due to impaired concentration and slowed mentation and in reduced adult height. Dans tous les cas, il est recommandé d'effectuer un bilan thyroïdien du nouveau-né et de la mère. Chez les femmes ménopausées présentant une hypothyroïdie et un risque élevé d'ostéoporose, les taux supra physiologiques de lévothyroxine doivent être évités. Thyroid hormones exert their physiologic actions through control of DNA transcription and protein synthesis. Therefore, initiate Levothyroxine sodium therapy immediately upon diagnosis. Many drugs and physiologic conditions affect the binding of thyroid hormones to serum proteins [see Drug Interactions (7)] . Treated children may manifest a period of catch-up growth, which may be adequate in some cases to normalize adult height. Les intoxications aiguës sont en général de gravité modérée en l'absence d'antécédents cardiaques, y compris lors d'ingestions accidentelles chez l'enfant. 3400930066188 (1989, RCP rév 29.01.2021) 30 cp 150 µg (plaq PVC/Alu). Dose Adjustments During Pregnancy and the Postpartum Period. Rifampin has been shown to accelerate the metabolism of Levothyroxine. 6 Aluminum Lake, FD&C Red No. For years, patients have been told that all they need is levothyroxine treatment to . Round shaped, Green colored, uncoated tablets, break line on both side and debossed with "P" and "12" on one side and plain on other side. Overtreatment may result in craniosynostosis in infants and premature closure of the epiphyses in children with resultant compromised adult height. Do not administer in foods that decrease absorption of Levothyroxine sodium tablets, such as soybean-based infant formula [see Drug Interactions (7.9)] . Cela peut résulter en une hypothyroïdie fœtale. Phosphate binders may bind to Levothyroxine. Tarif de référence (TR) 112.31. Round shaped, Pink colored, uncoated tablets, break line on both side and debossed with "P" and "11" on one side and plain on other side. Increase the dose every 6 to 8 weeks, as needed until the patient is clinically euthyroid and the serum TSH returns to normal. T4 is considered a reservoir or prohormone for T3, the biologically most active thyroid hormone. Dietary fiber decreases bioavailability of T4. Thyroxine is de-iodinated to form triiodothyronine (T3) in the peripheral tissues. Treat patients with adrenal insufficiency with replacement glucocorticoids prior to initiating treatment with Levothyroxine sodium [see Contraindications (4)] . Levothyroxine sodium tablets USP are available as follows: Levothyroxine sodium tablets are contraindicated in patients with uncorrected adrenal insufficiency [see Warnings and Precautions (5.3)] . Levothyroxine (Euthyrox, Synthroid, Levo-T, Unithroid, Levoxyl) is an inexpensive drug used to treat hypothyroidism. Warnings 1 Aluminum Lake, D&C Yellow No. Le soja peut diminuer l'absorption intestinale de la lévothyroxine. 3400930066249 (1999, RCP rév 29.01.2021) 30 cp 175 µg (plaq PVC/Alu). EUTROXSIG is used to treat: La lévothyroxine à forte dose ne doit pas être associée à certaines substances destinées à faire perdre du poids, comme les substances sympathomimétiques. Round shaped, Brown colored, uncoated tablets, break line on both side and debossed with "P" and "7" on one side and plain on other side. Dosing must be individualized to account for these factors and dose adjustments made based on periodic assessment of the patient's clinical response and laboratory parameters [see Dosage and Administration (2.4)] . In patients on a stable and appropriate replacement dose, evaluate clinical and biochemical response every 6 to 12 months and whenever there is a change in the patient’s clinical status. 3400930065891 (1998, RCP rév 29.01.2021) 30 cp 100 µg (plaq PVC/Alu). Monitor patients receiving concomitant Levothyroxine sodium and sympathomimetic agents for signs and symptoms of coronary insufficiency. 3400930190579 (2019, RCP rév 29.01.2021) 30 cp 100 µg (plaq prédécoupées PVC/Alu). The liver is the major site of degradation for both T4 and T3, with T4 deiodination also occurring at a number of additional sites, including the kidney and other tissues. Exceptionnellement, après une ingestion d'une dose massive mettant en jeu le pronostic vital, une plasmaphérèse ou une hémoperfusion sur charbon peuvent être envisagées. Troubles cardiovasculaires : tachycardie, arythmie par fibrillation auriculaire ou extrasystoles, hypertension, douleurs thoraciques, angor, insuffisance cardiaque congestive, collapsus cardiogénique. Synthetic T 4 is identical in chemical structure to the T 4 produced in the human thyroid gland.Levothyroxine sodium has the molecular formula C 15 H 10 I 4 … Consider changes in TBG concentration when interpreting T4 and T3 values. Assess the adequacy of therapy by periodic assessment of laboratory tests and clinical evaluation. Start at a lower starting dose in newborns (0 to 3 months) at risk for cardiac failure and in children at risk for hyperactivity (see below). The average full replacement dose of Levothyroxine sodium tablets is approximately 1.6 mcg per kg per day (for example: 100 to 125 mcg per day for a 70 kg adult). Concurrent use of ketamine and Levothyroxine sodium may produce marked hypertension and tachycardia. Generic levothyroxine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. T4 is metabolized to triiodothyronine (T3) peripherally by deiodination. Un suivi maternel post-partum permettra d'ajuster le traitement, si nécessaire. En cas de pathologie cardiaque équilibrée par le traitement (troubles coronariens, troubles du rythme), l'indication est à discuter au cas par cas. This drug is more popular than comparable drugs. It also helps to treat goiter (an enlarged thyroid gland). While the general aim of therapy is to normalize the serum TSH level, TSH may not normalize in some patients due to in utero hypothyroidism causing a resetting of pituitary-thyroid feedback. In addition, confusion and disorientation may occur. Levothyroxine is a thyroid medicine that replaces a hormone normally produced by your thyroid gland to regulate the body''s energy and metabolism. Generally, TSH is suppressed to below 0.1 IU per litre, and this usually requires a Levothyroxine sodium tablets dose of greater than 2 mcg per kg per day. Camp Road, Inform patients that it may take several weeks before they notice an improvement in symptoms. Data sources include IBM Watson Micromedex (updated 1 Apr 2021), Cerner Multum™ (updated 5 Apr 2021), ASHP (updated 6 Apr 2021) and others. ... Posted 5/24/2012 5:50 PM (GMT -6) Maggiemay - Thank you for your reply and the book reference and excerpts. Start Levothyroxine sodium tablets at the full replacement dose in otherwise healthy, non-elderly individuals who have been hypothyroid for only a short time (such as a few months). Inform patients that Levothyroxine sodium tablets should not be used as a primary or adjunctive therapy in a weight control program. 40 Aluminum Lake, FD&C Blue No. This hormone nuclear receptor complex activates gene transcription and synthesis of messenger RNA and cytoplasmic proteins. Comprime Sec. Chez les patients euthyroïdiens, le traitement par lévothyroxine ne fait pas maigrir. It comes as a tablet or capsule you take by mouth. 3400930158180 (2018, RCP rév 29.01.2021) 90 cp 137 µg (plaq PVC/Alu). Addition of Levothyroxine sodium therapy in patients with diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements. Inform patients that the Levothyroxine in Levothyroxine sodium tablets is intended to replace a hormone that is normally produced by the thyroid gland. Durham, NC 27703, Round shaped, Blue colored, uncoated tablets, break line on both side and debossed with "P" and "9" on one side and plain on other side. The dose should be adjusted based on clinical response and laboratory parameters, 3 to 4 days in hyperthyroidism, 9 to 10 days in hypothyroidism. C'est pourquoi une surveillance étroite de la fonction thyroïdienne est recommandée. Instruct patients to notify their healthcare provider if they are taking any other medications, including prescription and over-the-counter preparations. Liste-Prix Prix public (PPA) 112.31. Ils servent à produire des statistiques anonymes. Sau khi uống, cơ thể không phân biệt được hormon ngoại sinh với hormon nội sinh. Thyroid hormones are also metabolized via conjugation with glucuronides and sulfates and excreted directly into the bile and gut where they undergo enterohepatic recirculation. However, in patients with high-risk tumors, the target level for TSH suppression may be lower. EUTROXSIG is available in tablets of four different strengths: 50 micrograms, 75 micrograms, 100 micrograms and 200 micrograms. 3400930121405 (2017, RCP rév 29.01.2021) 90 cp 75 µg (plaq PVC/Alu). Oral Levothyroxine sodium is a synthetic T4 hormone that exerts the same physiologic effect as endogenous T4, thereby maintaining normal T4 levels when a deficiency is present. Select one or more newsletters to continue. 5 (tartrazine) sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity. Intas Pharmaceuticals Limited, Measure and evaluate unbound (free) hormone and/or determine the free-T4 index (FT4I) in this circumstance. Administration of sertraline in patients stabilized on Levothyroxine sodium may result in increased Levothyroxine sodium requirements. Potential impact: Administration of these enzyme inhibitors decreases the peripheral conversion of T4 to T3, leading to decreased T3 levels. However, there is insufficient information to determine the effects of Levothyroxine on the breastfed infant and no available information on the effects of Levothyroxine on milk production. Absorption of orally administered T4 from the gastrointestinal tract ranges from 40% to 80%. 3400930157930 (2018, RCP rév 29.01.2021) 30 cp 88 µg (plaq PVC/Alu). For patients with serum TSH above the normal trimester-specific range, increase the dose of Levothyroxine sodium by 12.5 to 25 mcg/day and measure TSH every 4 weeks until a stable Levothyroxine sodium dose is reached and serum TSH is within the normal trimester-specific range. Urinary excretion of T4 decreases with age. Levothyroxine is a medicine used to treat people with hypothyroidism. TLBones. Evaluate the need for dose adjustments when regularly administering within one hour of certain foods that may affect Levothyroxine sodium tablets absorption [see Drug Interactions (7.9) and Clinical Pharmacology (12.3)] . They include the following: Seizures have been reported rarely with the institution of Levothyroxine therapy. Les études conventionnelles de génotoxicité, de cancérogénicité et de toxicité des fonctions de reproduction n'ont pas été conduites avec la lévothyroxine. [see USP Controlled Room Temperature]. The relative bioavailability of Levothyroxine sodium tablets, compared to an equal nominal dose of oral Levothyroxine sodium solution, is approximately 93%. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Informations générales Forme. Circonstances, associées ou non à une hypothyroïdie, où il est nécessaire de freiner la TSH. Administer Levothyroxine sodium tablets to infants and children who cannot swallow intact tablets by crushing the tablet, suspending the freshly crushed tablet in a small amount (5 to 10 mL or 1 to 2 teaspoons) of water and immediately administering the suspension by spoon or dropper. Atrial arrhythmias can occur in elderly patients. Round shaped, Orange colored, uncoated tablets, break line on both side and debossed with "P" and "1" on one side and plain on other side. Administer Levothyroxine sodium tablets at least 4 hours before or after drugs known to interfere with Levothyroxine sodium absorption [see Drug Interactions (7.1)] . Adjust the dose in 12.5 to 25 mcg increments every 2 to 4 weeks until the patient is clinically euthyroid and the serum TSH level is normalized. Pharmacodynamic: Levothyroxine is deiodinated in peripheral tissues to form triiodothyronine which is thought to be the active tissue form of thyroid hormone. Although the overall incidence of FD&C Yellow No. Instruct patients to take Levothyroxine sodium tablets as a single dose, preferably on an empty stomach, one-half to one hour before breakfast. Administer thyroid hormone products formulated for intravenous administration to treat myxedema coma. Active Comparator: levothyroxine 100 pregnant female with TSH of> 2.5 mU/L but less than 4 mU/L after biochemical diagnosis of pregnancy will receive 50 ug of levothyroxine (eltroxin 50) aspen,Egypt throughout the pregnancy En cas de changement d'un médicament contenant de la lévothyroxine à un autre, une surveillance étroite (clinique et biologique) doit être instaurée pendant la période de transition en raison du risque potentiel de déséquilibre thyroïdien. Part of your endocrine system, your thyroid gland is located at the base of your throat and creates the hormones that control how quickly you use both oxygen and energy -- … There are risks to the mother and fetus associated with untreated hypothyroidism in pregnancy. Pregnancy, infectious hepatitis, estrogens, estrogen-containing oral contraceptives, and acute intermittent porphyria increase TBG concentration. Aux doses supérieures à 0,02 mg/kg, une légère vacuolisation cytoplasmatique des hépatocytes, une basophilie des cellules tubulaires du rein et des nécroses des cellules du muscle cardiaque ont été observées. Levothyroxine sodium, USP tablets are supplied as follows: Store at 25°C (77°F); excursions permitted to 15° to 30° C (59° to 86° F). 3400930190586 (2019, RCP rév 29.01.2021) 30 cp 50 µg (plaq prédécoupées PVC/Alu). WARNING: NOT FOR TREATMENT OF OBESITY OR FOR WEIGHT LOSS. Instruct patients to take Levothyroxine sodium tablets only as directed by their healthcare provider. Pituitary Thyrotropin (Thyroid‑Stimulating Hormone, TSH) Suppression. Larger doses may produce serious or even life threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects, Primary Hypothyroidism in Adults and in Adolescents in Whom Growth and Puberty are Complete, Pediatric Dosage - Congenital or Acquired Hypothyroidism, Newborns (0 to 3 months) at risk for cardiac failure, TSH Suppression in Well-differentiated Thyroid Cancer, Table 6. 3400930065556 (1989, RCP rév 29.01.2021) 30 cp 25 µg (plaq PVC/Alu). Inform patients that agents such as iron and calcium supplements and antacids can decrease the absorption of Levothyroxine. These drugs may cause protein-binding site displacement. If cardiac symptoms develop or worsen, reduce the Levothyroxine sodium tablets dose or withhold for one week and restart at a lower dose. EUTHYROX contains the active ingredient, levothyroxine, a synthetic crystalline levothyroxine (T 4) in sodium salt form.It is chemically designated as L-3,3',5,5'-tetraiodothyronine monosodium hydrate. Le traitement par lévothyroxine doit être impérativement poursuivi pendant toute la grossesse pour assurer l'équilibre maternel nécessaire au bon déroulement de la grossesse (et notamment réduire le risque d'hypothyroïdie fœtale).
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